AdvancedDocClean has the functionality. Please use BlankPageDetectionCommand and BlankPageDetectionResults. Sample codes are as below:
BlankPageDetectionCommand cmd = new BlankPageDetectionCommand();
cmd.SpeedFactor = RunSpeed.Fast; // Choose one among Normal, Fast, Faster, Fastest
cmd.MinObjectSize = new Size(30, 30); // noises of which size smaller then MinObjectSize will be ignored
BlankPageDetectionResults res = (BlankPageDetectionResults)cmd.Apply(image);
then the boolean res.IsImageBlank will tells you whether the page is blank or not.