A PDF does not have a resolution and can be zoomed into at any size, and the result will always look good. But, a TIFF is a bitmap -- it has a specific resolution and when you zoom in, the vector object that were in the PDF are gone -- all you can do is resample the TIFF. The higher the resolution the better it will look, but then you need more pixels, and that will make the file larger and use more memory as you have discovered.
There is no way to have a TIFF that can zoom in like a PDF.
If you are trying to zoom out and want the image to look good, make sure you are using our Document Imaging edition and keep ScaleToGray set to on -- then, if you have a black and white image, we will automatically convert to grayscale while zooming out so that the resized image looks good.